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Recombinant human bone morphogenetic proteins (rhbmps) are potent anabolic agents that promote the differentiation of mesenchymal progenitors into bone-forming osteoblastsin vitro and in vivo . J Bone Miner Res 16, 823–832 (2001). 69. Chabrol, S. et al. A human osteoprogenite precursor peptide: osteocalcin, a novel bone morphogenetic protein from the human lineage . Science 297, 1016–1019 (1999). 70. Fagot, D., Darrasch, V. & Meunier, J. H. A proteome-wide analysis of the gene architecture of human osteoblasts reveals novel gene product-like domains and a new functional variant . Ann. N Y Acad. Sci. 1046, 485–498 (2002). 71. Rizzon, R. & Rennie, T. V. A new bone morphogenetic protein from the human lineage: osteocalcin . Mol. Cell Biol. 4, 1–11 (2001). 72. Meunier, J., Lefler, J. & Bontin, L. E. Orthotopic bone morphogenetic protein-1 (obo1/O1g) . Nature 387, 818–821 (1996). 73. Meunier, J., Bontin, L. E., Gros, P. F., Korn, K. & Fagot, D. A human gene encoding an osteocalcin orthodon: implications for human osteogenesis, physiology and treatment . J. Am. Chem. Soc. 117, 2817–2825 (2001). This is the first report of O1g from the human lineage. 74. Meunier, J. & Fagot, D. Osteocalcin is a novel bone morphogenetic protein that interacts, activates and contributes to the formation of osteoblasts or osteoblasts-like cells after in vitro growth in primary cultures of human bone tissue . Bone 26, 1345–1353 (1995). 75. Leblanc, P. et al. Osteocalcin inhibits osteogenesis and promotes remodeling of osteonedema after acute myeloid leukemia . Blood 112, 3511–3518 (2000). 76. Fagot, D. & Pénicault, M. G. The osteocalcin receptor: a novel gene product from the human lineage . Am. J. Med. Genet. B Neuropsychiatr Genet. 145, 827–8 Related Article:

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